Revertor 5 mg/ml

Revertor 5 mg/ml is a clear, colorless solution for injection for dogs and cats containing the active substance atipamezole hydrochloride. This veterinary medicinal product is indicated to reverse the sedative effect of medetomidine in dogs and cats. Revertor 5 mg/ml is one of the veterinary medicinal products that may only be administered by veterinarians (UDD).

Revertor 5 mg/ml has the registration number REG NL 100708.

Indication

Atipamezole hydrochloride is a selective alpha2 antagonist and indicated to reverse the sedative effect of medetomidine and dexmedetomidine in dogs and cats.

Contraindication

Do not use on:

  • Breeding animals
  • Animals suffering from liver or kidney disease

See also "SPECIAL WARNINGS" in the leaflet.

Dosage

Revertor 5 mg/ml is suitable for single intramuscular administration, 15 to 60 minutes after administration of medetomidine or dexmedetomidine hydrochloride.

Dogs:

The intramuscular atipamezole hydrochloride dose is five times that of the preceding medetomidine hydrochloride dose or ten times that of the dexmedetomidine hydrochloride dose. Due to the five-fold higher concentration of the active ingredient (atipamezole hydrochloride) in this product compared to the concentration of preparations containing 1 mg medetomidine hydrochloride per ml and the 10-fold higher concentration compared to the concentration of preparations containing 0.5 mg dexmedetomidine hydrochloride, an equal volume of both preparations is required.

See the leaflet for a dosage example for dogs.

Cats:

The intramuscular atipamezole hydrochloride dose is two and a half times that of the preceding medetomidine hydrochloride dose or five times that of the dexmedetomidine hydrochloride dose. Due to the 5-fold higher concentration of the active ingredient (atipamezole hydrochloride) in this product compared to that of preparations containing 1 mg medetomidine hydrochloride per ml and the 10-fold higher concentration compared to the concentration of preparations containing 0.5 mg dexmedetomidine hydrochloride half the volume of the product relative to the previously administered medetomidine or dexmedetomidine should be given.

See the leaflet for a dosage example for cats.

 

The recovery time is reduced to approximately 5 minutes. The animal becomes mobile about 10 minutes after administration of the product.

Composition

One ml contains:

Atipamezole Hydrochloride 5.0 mg

Methyl parahydroxybenzoate (E218) 1.0 mg

 

Revertor 5 mg/ml is available in a 10 ml vial.

Side effects

A transient blood pressure lowering effect has been observed during the first 10 minutes after atipamezole hydrochloride injection. In rare cases, hyperactivity, tachycardia, salivation, atypical vocalization, muscle tremors, vomiting, increased respiratory rate, uncontrolled urine leakage and uncontrolled defecation may occur. In very rare cases, the re-entry of sedation may occur or the recovery time may not be shortened after administration of atipamezole.

In cats, when using low doses to partially reverse the effects of medetomidine or dexmedetomidine, care should be taken against the possibility of hypothermia (even after recovery from sedation).

Leaflet

Download the leaflet.

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