Cepesedan 10 mg/ml

Cepesedan 10 mg/ml is a veterinary medicinal product for sedation and mild analgesia for horses and cattle. Cepesedan 10 mg/ml is one of the veterinary medicinal products to be administered only by veterinarians (UDD).

Cepesedan 10 mg/ml has registration number NL 10472.


Sedation and mild analgesia of horses and cattle, to facilitate physical examination and treatment, such as minor surgery.

Detomidine can be used for:

  1. Investigations (e.g. endoscopy, rectal and gynecological examination, X-rays).
  2. Minor surgical procedures (eg treatment of wounds, treatment of teeth, treatment of tendons, excision of skin tumors, treatment of udders).
  3. Prior to treatment and medication (eg gastric intubation, shoeing of horses' hooves).

Premedication prior to administration of injection or inhalation anaesthetics.


  • Do not use in animals with heart defects or respiratory disease.
  • Do not use in animals with hepatic or renal impairment.
  • Do not use in animals with general health problems (eg dehydrated animals).
  • Do not use in combination with butorphanol in horses with colic.
  • Not to be used in the last trimester of pregnancy.


Cepesedan 10 mg/ml is suitable for intravenous (IV) or intramuscular (IM) administration. The product should be injected slowly. Onset of effect is faster after intravenous administration.

See the leaflet for a dosing schedule for short-term sedation in horses and cattle.

If prolonged sedation and analgesia is required, doses of 40 to 80 µg/kg may be used. The duration of the effect is up to 3 hours. If a combination with another product is used to enhance sedation or for premedication prior to general anaesthesia, a dose of 10 to 30 µg/kg may be used. It is recommended to wait 15 minutes after the detomidine administration before starting the planned procedure. The body weight of the animal to be treated should be determined as accurately as possible to avoid overdose.


One ml contains:

Detomidine hydrochloride 10 mg (equivalent to 8.36 mg detomidine)

Methyl parahydroxybenzoate (E218) 1 mg

Cepesedan 10 mg/ml is available in a 5 ml and 20 ml vial.

Side effects

  1. Bradycardia
  2. Temporary hypo- and/or hypertension
  3. Respiratory depression, rarely hyperventilation
  4. Rise in glucose levels in the blood.
  5. As with other sedatives, paradoxical reactions (excitations) may develop in rare cases.
  6. Ataxia.
  7. Uterine contractions.
  8. In horses: cardiac arrhythmias, atrioventricular and sino-atrial blockade.
  9. In cattle: inhibition of rumen motility, tympania, paralysis of the tongue.


Download the leaflet.


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